Are you concerned about thyroid nodules? I have something that might be able to help. It’s part of our whole new line of Thyroid Specific Formulations. This one is called Nodule Control, and I want to tell you all about it.
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Table of Contents
Worried About Thyroid Nodules?
What Are Thyroid Nodules?
Thyroid Nodule Control: The Benefits
How Do You Take Nodule Control?
How Is Nodule Control Formulated?
How Does One Construct Thyroid Specific Formulations?
Nodule Control: Ingredients
Three Supportive Strategies For Thyroid Nodules
How Should You Take Nodule Control?
Nodule Control: Cautions
Worried About Thyroid Nodules?
That’s totally fair, because thyroid nodules can be serious attention-getters. In fact, I’d say that any rational person walking around with a precancerous tumor would want it gone.
Key Insight: The positive part is that supplements alone can shrink them substantially. I go into more detail below, but the studies back this up and add credence to this point.
So, when it comes to Thyroid Nodule Control, what’s in it? How does it work? Here is all the detailed information I wrote for the product monograph, prepared for you.
What Are Thyroid Nodules?
Thyroid nodules are abnormal growths of thyroid tissue.
They may be solid or fluid-filled. Nodules are common and become even more common with age. Roughly half of all people will have thyroid nodules by the time they turn 60.1
Key Insight: Thyroid nodules rarely cause symptoms. But, if they are large enough, they can cause discomfort or difficulty in swallowing or breathing.
In addition to that, thyroid nodules present a risk for thyroid cancer. Roughly 4% of womens’ nodules contain thyroid cancer as in their thyroid nodules’ size.2
There is no known single cause for thyroid nodules, but they are more common with:
- Age
- Excessive iodine intake
- Higher body weight
The mechanisms of action of supplements that may help reduce thyroid nodules include those that slow rates of cell division, those that act as anti-inflammatories, and those that regulate iodine metabolism.
Thyroid Nodule Control: The Benefits
The ingredients that can be found in Nodule Control have been clinically proven to:
- Slow down the rate of nodule growth.
- Reduce the size of existing thyroid nodules.
- Lower the overall risk of thyroid nodules progressing into thyroid cancer.
Sounds like a pretty great combination, right? Later on, I’ll show how the science behind it proves this out, but let’s talk a bit more in detail about Nodule Control itself.
How Do You Take Nodule Control?
All you have to do is take two pills, once daily, in the morning and with food. You should use Nodule Control alongside the recommended monitoring and treatment of thyroid nodules.
How Is Nodule Control Formulated?
Two caps of Nodule Control will contain:
- 400 mg of Spirulina
- 50 mg of Boswellia
- 50 mg of Turmeric
- 100 mg of Inositol
- 25 mcg of Selenium
- 25 mg of Prunella
How Does One Construct Thyroid Specific Formulations?
This is important. In this case, every single ingredient considered must share the following properties to warrant inclusion…
Thyroid Safety
All considered ingredients must be natural compounds that have been safely consumed by humans for centuries. They must be generally recognized as safe (GRAS) by toxicologists. Finally, they must not contain unsafe levels of iodine.
Evidence & Efficacy
All considered ingredients must have high-quality evidence proving their efficacy. The best quality evidence is that which demonstrates significant positive outcomes, on human subjects, in multiple, double-blinded controlled studies.
Ultimately, these human subjects and the outcomes should be clinically relevant to the product’s end-users. It needs to mean something for them.
Nodule Control: Ingredients
The following is a complete breakdown of the active ingredients found in Nodule Control. It includes their relevance to thyroid disease, mechanisms of action, and a review of supportive research.3
Spirulina
Spirulina is a rich source of the antioxidant superoxide dismutase (SOD) which is one of the endogenous antioxidants that allows for normal thyroid cell replication.
The thyroid cells are exposed to high amounts of free radical damage from the formation of iodine and its attachment to thyroglobulin.
Unchecked free radical formation can lead to DNA damage that can result in the abnormal cell growth behind nodule formation and thyroid cancer.
Boswellia
Boswellia is a tree resin with antiinflammatory effects which block NFkB pathways and normalize the activity of regulatory and effector T cells.4
Turmeric
Turmeric has been shown to benefit oxidative pathways involved with nodule formation such as IL-6, hs-CRP, and MDA.5
In a double blinded human clinical trial, the combination of spirulina, boswellia, and turmeric was tested for its ability to reduce thyroid nodules.
In the study, adult patients with thyroid nodules were given a combination of the three nutrients or a placebo over the period of 6 weeks. Thyroid ultrasounds to evaluate nodule size were performed at the beginning of the study, after 6 weeks, and after 12 weeks.
Of those taking the nutrient combination, over 85% showed a significant decrease to the size of their thyroid nodules. The average reduction in nodule size for those on the active treatment ranged from 0.6 to 0.9 cm2.
It was noted that the results are especially significant in light of the fact that the supplements were only administered for the first half of the study. They might have been even more pronounced had they been taken for the full 12 weeks. 6
Inositol
Inositol is a natural occurring sugar that is a conditionally essential nutrient. It has been shown to help regulate cell proliferation, morphogenesis, and glucose regulation.7
Selenium
Selenium is essential for nearly all facets of thyroid function including iodine regulation, cell proliferation, and regulation of free radicals within thyroid follicles.
In a recent clinical trial, the combination of inositol and selenium was tested for its ability to reduce the mass of thyroid nodules. A total of 642 patients were evaluated for nodules. The average age of the patients was 41 and roughly 90% were female. Of them, 333 were randomly assigned to treatment with inositol and selenium or usual therapy.8
Of those treated, none developed thyroid cancer. The average nodule size was reduced by 26% (16.7 mm to 12.4 mm). No significant change in nodule size was seen in the control group.
Those treated with inositol plus selenium also saw their TSH scores go down from an average of 4.2 to 2.1. TSH scores in the control group went up from an average of 3.95 to 4.3.
Prunella
Prunella vulgaris is an herb used in traditional Chinese Medicine. Also called heal-all, it is used as a common ingredient in teas and is used as a vegetable.9 It has a wide range of historical applications including the treatment of abnormal growths and tumors.
A recent meta-analysis reviewed 11 randomized clinical trials totaling 1215 patients. It concluded that prunella caused:
“Improvement of thyroid function and thyroid autoantibodies, shrinkage of thyroid gland and nodule[s], and improvement of clinical symptoms such as fatigue and cold intolerance”10
In vivo and in vitro studies have shown that prunella promotes apoptosis in thyroid cancer calls.11
Three Supportive Strategies For Thyroid Nodules
So, what are some strategies you can undertake to deal with thyroid nodules? Beyond using Nodule Control, here are some places to start:
1. TSH Regulation
Thyroid nodules often grow in proportion to elevated TSH levels. Avoidance of TSH elevation and TSH suppression to a range of 0.4 to 0.6 may reduce the size of benign nodules.12
2. Iodine Reduction
Excessive intake of iodine, even to small degrees, may promote the growth of thyroid nodules. Iodine reduction to a healthy intake of 50 – 200 mcg daily may improve the odds of nodule reduction.13
3. Weight Loss
Insulin resistance as associated with excess body weight may increase the likelihood of thyroid nodule formation and nodule growth.14 Modest weight loss of 5-10% of body weight may improve the odds of nodule reduction.
How Should You Take Nodule Control?
Take two capsules daily with food. Keep in mind: You should take Nodule Control at least one hour after taking any thyroid medications.
What Doesn’t Nodule Control Contain?
Nodule control does not contain:
- Caffeine
- Stimulants
- Thyroid hormones
- Iodine
- GMO
- Gluten
- Dairy
Nodule Control: Cautions
The ingredients listed have not been studied in pregnant or lactating women and should be avoided.
Those on thyroid medication may need a reduction in their dosage due to the usage of this product. Please work with your prescriber to monitor your thyroid levels regularly and report any new symptoms or changes to existing symptoms.
Try Nodule Control Today
Now that you know a bit more about it, how about trying it for yourself? If you’re interested in dealing with and shrinking your thyroid nodules, then Nodule Control may be perfect for you.
1 – Thyroid Nodules | American Thyroid Association. https://www.thyroid.org/thyroid-nodules/. Accessed May 27, 2021.
2 – Thyroid Nodules | Hormone Health Network. https://www.hormone.org/diseases-and-conditions/thyroid-nodules. Accessed May 27, 2021.
3 – Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. Arch Toxicol. 2016 Aug;90(8):1817-40. doi: 10.1007/s00204-016-1744-5. Epub 2016 Jun 3. PMID: 27259333.
4 – Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts. Beghelli D, Isani G, Roncada P, Andreani G, Bistoni O, Bertocchi M, Lupidi G, Alunno A
Oxid Med Cell Longev. 2017; 2017():7468064.
5 – The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi Z Phytother Res. 2019 Feb; 33(2):253-262.
6 – Stancioiu F, Mihai D, Papadakis GZ, Tsatsakis A, Spandidos DA, Badiu C. Treatment for benign thyroid nodules with a combination of natural extracts. Mol Med Rep. 2019;20(3):2332-2338. doi:10.3892/mmr.2019.10453
7 – Dinicola S, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol 2014; 54: 1079-1092.
8 – Nordio M, Basciani S. Evaluation of thyroid nodule characteristics in subclinical hypothyroid patients under a myo-inositol plus selenium treatment. Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):2153-2159. doi: 10.26355/eurrev_201804_14749. PMID: 29687875.
9 – Bai Y, Xia B, Xie W, Zhou Y, Xie J, Li H, Liao D, Lin L, Li C. Phytochemistry and pharmacological activities of the genus Prunella. Food Chem. 2016 Aug 1;204:483-496. doi: 10.1016/j.foodchem.2016.02.047. Epub 2016 Feb 16. PMID: 26988527.
10 – Zhang YL, Hu RX, Zhao H, Yang W, Yu DD, Li HM, Liao X, Gu H. [Systematic review and trail sequential analysis of preparation of Xiakucao for Hashimoto’s thyroiditis]. Zhongguo Zhong Yao Za Zhi. 2020 Dec;45(23):5777-5788. Chinese. doi: 10.19540/j.cnki.cjcmm.20200909.501. PMID: 33496119.
11 – Yu F, Zhang L, Ma R, Liu C, Wang Q, Yin D. The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo. Evid Based Complement Alternat Med. 2021 Jan 8;2021:8869323. doi: 10.1155/2021/8869323. PMID: 33505511; PMCID: PMC7811421.
12 – Yousef A, Clark J, Doi SA. Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules: a quality-effects meta-analysis. Clin Med Res. 2010;8(3-4):150-158. doi:10.3121/cmr.2010.881
13 – Katagiri R, Yuan X, Kobayashi S, Sasaki S. Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies. PLoS One. 2017;12(3):e0173722. Published 2017 Mar 10. doi:10.1371/journal.pone.0173722
14 – Yasar HY, Ertuğrul O, Ertuğrul B, Ertuğrul D, Sahin M. Insulin resistance in nodular thyroid disease. Endocr Res. 2011;36(4):167-74. doi: 10.3109/07435800.2011.593011. PMID: 21973236.
P.S. Whenever you are ready, here is how I can help you now:
1. Schedule a Thyroid Second Opinion with me, Dr. C, Click Here for Details
2. Need A Thyroid Supplement Recommendation? Take My Thyroid Specific Formulations Quiz Now
3. Need a Personalized Supplement? Check out My Thyroid Specific Formulations
4. Download and use my Favorite Recipes Cookbook Here
5. Check out my podcast Medical Myths, Legends, and Fairytales Here
Dr. Alan Glen Christianson (Dr. C) is a Naturopathic Endocrinologist and the author of The NY Times bestselling Adrenal Reset Diet, The Metabolism Reset Diet and The Thyroid Reset Diet.
Dr. C’s gift for figuring out what really works has helped hundreds of thousands of people reverse thyroid disease, lose weight, diabetes, and regain energy. Learn more about the surprising story that started his quest.
