How to Raise T2 Naturally and Boost Metabolism

Have you ever heard of T2 thyroid hormone? I’m sure you know of T4. Maybe even T3 and its role in your health. But, T2 may just be the unsung hero in your thyroid’s spectrum of hormones.

That’s why, today, I’m dedicating some time to share with you how T2 works. We will dive into the data, the results, and how T2 as a thyroid hormone can play a pivotal role in your health.

Here’s everything you need to know about T2.

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What Do The Numbers Mean?

How do we make sense of the numbers that follow T4, T3, and T2?
Well, to start, the T here stands for “thyroglobulin.” It’s a protein which is a modification of what we know as tyrosine.

Put simply, I think of thyroglobulin as a coat hanger. Think of a long gray bar where multiple coats could sit, in all different positions. You could have two, three, four coats, but the hanger ultimately remains the same – it’s the quantity of coats that changes.

The coats, in this case, are iodine atoms. Generally speaking, your body utilizes these hormones by breaking down these iodine items and changing the hormone in the process.

When they are all gone, you are left with an inactive protein.

What About T1?

So, I just introduced a handful of T-related concepts, but what happened to T1? I have never seen clear evidence that T1 truly does anything.

But, for our purposes, it’s more beneficial to focus on T2 thyroid hormone – because it has been proven to do something.

How T2 Works

What is also clear is that the thyroid does make T2.

For a long time, we thought that T2 only came from your body breaking down T4 and T3. But, now there is clear evidence that your thyroid is actively making T2.

So, why is it even worth thinking about T2?

The simple answer is that, if you have thyroid disease, you may be low in T2. While it was always assumed that you would be low in T3 and T4, it was often ignored how important T2 is to your body.

As part of thyroid hormone deficiency, T2 thyroid is not spared. And, even more importantly, T2 does things that T3 does not (Read More: How High Should Your T3 Be?).

Many talk about this idea that T2 is “inactive” (like T1 or reverse T3). While this is partially true of different kinds of T2, it’s worth breaking down even further to better understand.

It is all based upon where those aforementioned iodine atoms are attached.

There is:

• 3,5 T2
• 3,3 prime T2
• 3 prime 5 prime T2¹

From here on out, when I use the term T2 I will be referring to the first (3,5 T2).

How T2 Thyroid Hormone Works

Of all the things that T2 does, a lot of it comes down to this concept of basal metabolic rate.

This may be even more relevant than T3 or T4. Especially if you are not making your own thyroid hormone, you are not ingesting T2 and likely to be low in it³.

There were some studies that showed people who had their thyroid removed, and it saw where their T2 levels were at that point. Basically, they had about half as much.

Even when they were taking thyroid hormone replacement, their T2 levels weren’t high enough compared to healthy populations.

We have also seen the same thing in pregnant women. This is where their levels are much lower than those of healthy populations, too⁴.

Entering the Thyroid Renaissance

This whole conversation around T2 is part of a much larger discussion I’ve been having lately, and after coining the term “the thyroid renaissance.”
Of course, this is something so important to me. Revisiting the thyroid, its value in the body, and challenging some of those past assumptions is essential. It’s our chance to come out with newer, better, and more impactful insight for your health!

Things like thyroid Hormone deficiency, thyroid hormone replacement weight loss, and the effect of thyroid hormone on muscles, they are all such crucial topics and deserve things written about them! But, let’s focus on T2.

Back in the 70’s, there was a lot of research done on T2. This was to see if it were an important part of thyroid hormone replacement and to see if it could be used to lower cholesterol.

What we have known for quite some time is that those with low levels of thyroid hormone often have higher levels of blood cholesterol.

Case Study: T2 Thyroid Example

In fact, this reminds me of a conversation I had with my doctors a few days ago.

We were discussing the case of a woman who was seen to be severely low in thyroid. With TSH scores in the 100s, and free hormones hovering around 0, with cholesterol levels in the 300 – 400 range.

This was a serious case.

Right then and there, you can see the strong link between your thyroid and your cholesterol levels. It’s incredibly intertwined and impossible to ignore.

The Resulting Data

So, what did the researchers in the 70’s find?

Well, what they wanted was a thyroid hormone that could:

• Lower cholesterol, and
• Not create hyperthyroidism

For that, they broke down and studied T2. What they found, and what we know now, is that T2 affects oxygen consumption (faster than T3)⁵.

We also know that T2 is required to activate many detoxification enzymes⁶.
There are studies that show T2 increasing synthesis from the ATP to the mitochondria⁷.

It also activates our brown adipose tissue. Essentially, that’s the fat that burns fat⁸.

T2 is also important when it comes to:

• Maintaining muscular activity⁹
• Helping the liver and muscles burn fat
• Protecting renal function¹⁰
• Treating and optimizing your muscles¹¹
• Predicting lower body mass and better blood sugar¹²
• Affecting and improving cholesterol¹³

What Happens When People Take T2?

Here’s the thing – very few studies have been performed on the effects of T2 on humans. But, the data that we can see is quite encouraging.

The one, high-quality study that I saw was a placebo-controlled one¹⁴. They gave humans supplemental T2 for 28 days. What they saw was a spontaneous weight loss of about 9 pounds.

This happened without there being changes to:

• Free T3
• Free T4
• TSH Levels (Read More: Should You Ignore Your TSH?

There were also no cardiac side effects noticed. Because of these effects, further work is being undertaken to learn more and more about the positive effects of T2 and thyroid hormone replacement weight loss.

What Do You Do If You’re Low In T2?

Don’t take T2 Pills!

You’ll be logical to hear about her tea to help rush off and take T2 in a pill. But the problem is that synthetic T2 in the pills is not the same as your body making T2.

In fact, it is dangerous.

T2 supplementation is currently unregulated as a nonprescription product. No forms of prescription T2 exist. The drawback to supplementing with T2 is that it is impossible to track blood levels. The other problem is that T2 supplementation can bioaccumulate to dangerous levels within the liver.23

Preclinical studies have shown that supplementing with T2 supplements can lead to cardiac damage in as little as four weeks.

If low T2 is suspected, the most effective approach is improving the body’s ability to regulate it and other thyronamines. T2/T3 Converter can safely help the body regulate its thyroid hormones.

Take T2/T3 Converter

If you have symptoms of Low T2, the solution is to help your body, make it better by itself.

Thankfully, nutraceuticals that help your deiodinase enzymes can help you make all the T2 you need!

The thyroid is crazy complex! It makes different hormones like T4, T3, and others. The gland sends out some, but most of the hormones get made as T4 travels around the body. T4 changes into other hormones through pathways called deiodination. It’s like a hormone conversion factory!

There’s the classic deiodination path done by enzymes called deiodinases (D1, D2, D3). D1 is in the liver and kidney, D2 in the brain and muscles, and D3 in the placenta.

Then there are alternate pathways where hormones get deactivated, like T3 to reverse T3. That happens through steps like glucuronidation, sulfation, cleavage, and deamination.

If the conversion goes wonky, you can end up with too much or not enough of each hormone. That causes hypo or hyperthyroid symptoms even if the overall levels look normal.

Here are some key hormones and conversion issues:

• T4: Main hormone from the thyroid. High in hyperthyroidism or too much T4 meds. Low if untreated hypo or on T3-only.
• T3: Active hormone precursor to T2. Low in some on T4 meds with hypo symptoms. High in hyperthyroidism or T3 meds.
• Reverse T3: Deactivated T4. High in inflammation disease. Causes lingering hypo symptoms.
• T2: Underappreciated but vital. Low in thyroid meds or elderly. Lacking causes hypo symptoms. Can’t test it!

Supplements can help optimize conversion:

• • Selenium – Makes glutathione to protect the thyroid. Boosts deiodinases.
  • Vitamin E – Prevents disruption of D1 by free radicals.
  • Zinc – Controls all deiodinases. Affects TSH, T4, and T3.
  • D-Limonene – Makes glucuronides to improve colon recycling.
  • Ellagic acid – Supports receptors, adipose T3. Lowers reverse T3.
  • Curcumin – Protects thyroid, and prevents T3 lowering from inflammation.
  • Grape seed extract – Controls hypervascularity and inflammation.

So in summary, the thyroid hormone factory is complex! Conversion issues are common but can be improved with a supplement protocol along with managing hypo or hyperthyroidism. Keep your hormone pathways happy!

Take The Thyroid Quiz Today

Now that we know a bit more about T2, how about your check-in with your health?

Take the Thyroid Quiz (Click Here) today. It’s your chance to learn more about your health, your thyroid, and the essential relationship they share with one another.

You’ll get results and an action plan to put your health in your own hands. So, please give it a try today, and I can’t wait to hear how it helps you!

P.S. Whenever you are ready, here is how I can help you now:

1. Schedule a Thyroid Second Opinion with me, Dr. C, Click Here for Details
2. Need a Personalized Supplement? Check out My Thyroid Specific Formulations
3. Download and use my Favorite Recipes Cookbook Here
4. Check out my podcast Medical Myths, Legends, and Fairytales Here

Dr. C’s gift for figuring out what really works has helped hundreds of thousands of people reverse thyroid disease, lose weight, diabetes, and regain energy. Learn more about the surprising story that started his quest.