First, you can do it empirically. What that means is that if you take histamine blockers, and feel better, it is not unreasonable to think that histamine intolerance was the root of the problem. The difficulty here is that histamines have a great deal of influence on your body. It can affect your:
- Overall mood
- State of anxiety
- Stress or panic levels
These are all things that histamines effect, and that histamines lower! This all goes back to the fact that things like anxiety can trigger responses like rashes, and in taking an antihistamine we can sedate ourselves and feel better (and less anxious).
Even though anxiety was our overall issue, we might attribute it to a histamine intolerance instead.
The other difficulty with histamine has to do with its production in the body. Your body makes histamine in response to allergies, infections, stress, or trauma, but we also do get it from some foods in our diet.
Certain bacterial events can even make the amine levels in foods lethal, and have caused issues in the past. This thinking, though, has led people to believe that the levels of histamines in certain foods can act as a trigger.